Abstract: Primary angle-closure glaucoma (PACG) is a kind of glaucoma with similar anatomical structure characteristics ( shallow anterior chamber, relatively small cornea, relatively thick lens, short axial length, etc. ). The common cause of PACG is acute or chronic closure of the anterior chamber angle, which hinders the outflow of aqueous humor, increases intraocular pressure, and leads to visual impairment. Iris tissue structure plays an important role in the pathogenesis. Previous studies have mostly focused on the characteristics of iris static anatomy. However, not all suspected primary angle closure (PACS) individuals with similar anatomical features will develop into PACG. With the development of anterior segment imaging technology, recent studies have found the abnormal iris dynamic changes, such as the iris tissue structure, dynamic changes, biomechanical properties and autonomic nerve function, etc., play the important roles on the early screening of PACG and the prediction of PACS disease progression.

Key words: primary angle-closure glaucoma, dynamic changes of iris, biomechanics, autonomic nerve function, clinical intervention